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Clinical Research

We offer hope to those with retinal diseases by providing access to clinical trials that could potentially improve their condition and advance the treatment outcomes for future patients

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Current Clinical Trials

Diabetic Macular Edema (DME)
Geographic Atrophy (GA)
Intermediate Age-Related Macular Degeneration (iAMD)
Macular Telangiectasia (MacTel)
Wet Age-Related Macular Degeneration (wAMD)

Diabetic Macular Edema (DME)

THULITE

Boehringer Ingelheim

A Phase 2 randomized, double-masked, placebo-controlled trial to evaluate the efficacy, safety, and tolerability of oral BI 1815368 in participants with center-involved diabetic macular edema for 48 weeks of treatment

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THAMES

Genentech

A Phase I/II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7446603 Administered Alone or in Combination with Aflibercept or Faricimab in Patients with Diabetic Macular Edema

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PREGONDA

Roche

A Multi-Center, Non-Randomized, Open-Label, Multiple Ascending Dose, Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7497372 Following Intravitreal Administration in Participation with Diabetic Macular Edema

Geographic Atrophy (GA)

ARCHER II

Annexon

A Phase 3 Study Investigating the Efficacy and Safety of Intravitreal Injections of ANX007 in Patients with Geographic Atrophy (GA)

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ReNEW

StealthBio Therapeutics

ReNEW: A Phase 3, Double-Masked, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects Who Have Dry Age-Related Macular Degeneration (Dry AMD)

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JADE

Boehringer Ingelheim

Phase II trial in patients with geographic atrophy: A randomized, double-masked, placebo-controlled, dose-finding study to evaluate the efficacy and safety of oral BI 1584862

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VERDANT

Boehringer Ingelheim

A Phase 2 Randomized, double-masked, active-controlled, multicenter study to evaluate efficacy and safety of two regimens of intravitreal BI 771716 against pegcetacoplan in participants with geographic atrophy secondary to age-related macular degeneration

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GARLAND

Apellis Pharmaceuticals, Inc

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World
Safety, Tolerability and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients with
Geographic Atrophy Secondary to Age-Related Macular Degeneration

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PARASOL

Janssen

A Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

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Intermediate Age-Related Macular Degeneration (iAMD)

HONU

Genentech

Injection of 4D-150 in Adults with Macular Neovascularization Secondary to Age-Related

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Macular Telangiectasia (MacTel)

NHOR

The Lowy Medical Research Institute

The Natural History Observation Registry (NHOR) is a world-wide registry of individuals with Macular Telangiectasia type 2, and their family members.

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Wet Age-Related Macular Degeneration (wAMD)

SOL

Ocular Therapeutix

A Phase 3, Multicenter, Double-Masked, Randomized, Parallel-Group Study to Evaluate the Efficacy and Safety of Intravitreal OTX-TKI (Axitinib Implant) in Subjects With Neovascular Age-Related Macular Degeneration (nAMD)

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ASCENT

AbbVie

A Randomized, Partially Masked, Controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants With nAMD

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PROTOCOL AO

DRCR

This study compares Home OCT-Guided Treatment versus Treat and Extend for the management of neovascular (wet) AMD.

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4FRONT-1

4D Molecular Therapeutics

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 Gene Therapy in Adults with Macular Neovascularization

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DME
GA
iAMD
MacTel
wAMD

Closed Trials

AERIE

ALTISSIMO

AVANTE

BHAM

ALEXION

ARCHWAY

AVENUE

BI GA

ALLUVIUM

ASPIRE

BARDENAS

BOULEVARD

DERBY

GALE

NTMT

PREGONDA

DRCR

GALLEGO

OMASPECT

RAVEN

FOCUS

KINGFISHER

PANDA

RHINE

SAPPHIRE

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STAMP

VAPOR

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SPECTRI

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SUSHI

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STAIRWAY

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